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ROS generation occurs via multiple metabolic pathways that are tightly controlled by oxidant and antioxidant signaling and plays an important role in modulating inflammation during viral infections 21,22
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Additionally, it increases the levels of ferroptosis markers (e.g., Slc7a11 and Gpx4), which predispose PDAC cells to ferroptosis under conditions of Gln deprivation, thereby providing a combined strategy for PDAC therapy (49)
Summary Although there is evidence for an interaction between GST genes, and environmental exposures in relation to asthma, results are not concordant